白癜风诊疗康复 http://pf.39.net/bdfyy/bdfal/index.htmlBLymphocytesandMacrophagesinthePerivascularAdiposeTissueAreAssociatedWithCoronaryAtherosclerosis:AnAutopsyStudyJAHAresearch-articleDec17,:8(24),e./JAHA..本文由“天纳”临床学术信息人工智能系统自动翻译点击文末“阅读原文”下载本文PDFBackgroundMacrophagesandTlymphocytesintheperivascularadiposetissue(PvAT)werepreviouslylinkedtocoronaryarterydisease.However,theroleofthesecellsandBlymphocytesinthehumanPvATadjacenttounstableatheroscleroticplaqueshasnotbeeninvestigated.Moreover,previousstudieswereinconclusiveonwhetherPvATinflammationwasrestrictedtothesurroundingsoftheatheromaplaque.血管周围脂肪组织（PvAT）中的巨噬细胞和T淋巴细胞先前与冠状动脉疾病有关。然而，这些细胞和B淋巴细胞在不稳定动脉粥样硬化斑块旁的人PvAT中的作用尚未被研究。此外，先前的研究对于PvAT炎症是否局限于粥样斑块周围没有定论。MethodsandResultsCoronaryarterieswerefreshlydissectedwiththesurroundingPvAT.Atheroscleroticplaqueswereclassifiedaccordingtotheinternationallyacceptedanatomopathologicalcriteria.ImmunecellsinthePvATweredetectedusingimmunohistochemistryandthenquantified.Weusedlinearandlogisticregressionswithrobuststandarderrors,adjustedforpossibleconfoundingfactors.Inatheroscleroticplaques(stableand41unstableplaques)from82participants(meanage=69.0±14.4?years;50%men),thepercentageofarterialobstructionwaspositivelycorrelatedwiththedensitiesofCD68macrophages(P=0.)andCD20Blymphocytes(P=0.03)intheperiplaquePvAT.ThenumberofcellswasgreaterintheperiplaquePvATthaninthedistalPvAT(macrophages,P0.;Blymphocytes,P=0.04).Inaddition,thedensityofmacrophagesintheperiplaquePvATwasgreaterinthepresenceofunstableplaques(P=0.03)andwasalsogreaternearunstableplaquesthaninthedistalPvAT(P=0.).CD3Tlymphocyteswerenotassociatedwithpercentageofobstructionandstable/unstableplaque